This is more of a mobile shop hack:
Your standard in-bed pickup truck toolbox sits snug against the cab. The trade-off there is that you preserve some bed space, but sacrifice convenience; fishing around in a chest-style toolbox can be unergonomic, to say the least.
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Farmer Derek Anthofer uses his truck as an on-farm service vehicle, and wanted a better way to quickly access tools as he makes repairs around the property. He designed and built a slant-top steel toolbox mounted to an in-bed pivot, which you can see in the video below. (Also look for the handy pop-in vise he keeps in the modified service trailer.)